Opportunity Information: Apply for HT942526TBDRPTDRA
The FY26 Tick-Borne Disease Research Program (TBDRP) Therapeutic/Diagnostic Research Award (TDRA) is a Department of the Army (USAMRAA) grant opportunity designed to fund product-driven research that moves practical therapies and diagnostics closer to real-world use for Lyme disease and other tick-borne diseases and related conditions. The central focus is on reducing disease burden while improving patient care and quality of life, with proposals expected to be oriented toward tangible deliverables rather than purely exploratory or basic research.
On the therapeutics side, the award is aimed at therapeutic evaluation work that supports early or preclinical development, specifically studies that help advance new concepts in drug or treatment discovery. This framing suggests projects should be positioned to generate the kind of evidence needed to justify the next development step, such as refining a candidate intervention, demonstrating proof-of-concept in appropriate models, characterizing activity and feasibility, or producing data that de-risks later-stage development. The opportunity is not described as supporting late-stage clinical trials; instead, it emphasizes ideas that are still early but moving toward a defined therapeutic product.
On the diagnostics side, the program seeks approaches that can be readily integrated into clinical settings, meaning proposals should be geared toward tests or diagnostic workflows that can realistically fit into healthcare practice. That generally implies attention to practical implementation considerations such as clinical usability, feasibility in typical laboratory or point-of-care environments, and a clear pathway toward adoption in patient care. The intent is to support diagnostics development that is not just technically interesting, but designed for eventual routine clinical use.
Administratively, this is a discretionary grant opportunity under the Science and Technology and other Research and Development activity category (CFDA 12.420). Eligible applicants are listed as unrestricted, indicating the program is open to a broad range of applicant organizations rather than being limited to a narrow class. The funding opportunity number is HT942526TBDRPTDRA, and the opportunity is issued by the Department of the Army, USAMRAA. The posting indicates an anticipated total of two awards. The original closing date is October 22, 2026, and the opportunity was created on May 5, 2026. Additional details and any pre-announcement context are referenced through the CDMRP page at https://cdmrp.health.mil/pubs/press/2026/tbdrppreann.Apply for HT942526TBDRPTDRA
- The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoW Tick-Borne Disease Therapeutic/Diagnostic Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2026-05-05.
- Applicants must submit their applications by 2026-10-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted.
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FY26 Tick-Borne Disease Research Program (TBDRP) Therapeutic/Diagnostic Research Award (TDRA) FAQs
1) What is the FY26 TBDRP Therapeutic/Diagnostic Research Award (TDRA)?
The TDRA is a Department of the Army (USAMRAA) discretionary grant opportunity that funds product-driven research to move practical therapies and diagnostics for Lyme disease and other tick-borne diseases (and related conditions) closer to real-world use. The emphasis is on reducing disease burden and improving patient care and quality of life through tangible deliverables, not purely exploratory or basic research.
2) Which agency issues this funding opportunity?
This opportunity is issued by the Department of the Army through USAMRAA (U.S. Army Medical Research Acquisition Activity).
3) What is the funding opportunity number?
The funding opportunity number is HT942526TBDRPTDRA.
4) What program is this opportunity part of?
It is part of the FY26 Tick-Borne Disease Research Program (TBDRP) and specifically supports the Therapeutic/Diagnostic Research Award (TDRA) mechanism.
5) What diseases or conditions are in scope?
The opportunity targets Lyme disease and other tick-borne diseases, as well as related conditions, with the overarching goal of reducing disease burden and improving patient outcomes and quality of life.
6) What kind of research is the TDRA intended to support?
The TDRA is intended to support product-driven research that advances practical therapies and diagnostics toward real-world use. Proposals are expected to be oriented toward tangible deliverables rather than being primarily basic, exploratory, or purely discovery-focused.
7) Does this award support therapeutic research, diagnostic research, or both?
Both. The TDRA supports (1) therapeutic evaluation work aligned with early or preclinical development and (2) diagnostic approaches designed to be readily integrated into clinical settings.
8) What does the program mean by "product-driven" research?
Based on the description provided, "product-driven" means the proposed work should move a practical therapy or diagnostic closer to real-world use and include tangible deliverables. The program is looking for research oriented toward development progress, not only generating knowledge for its own sake.
9) What stage of therapeutic development is the TDRA aiming to fund?
On the therapeutics side, the award is aimed at early or preclinical development and therapeutic evaluation work. The intent is to support studies that advance new concepts in drug or treatment discovery toward a defined therapeutic product.
10) What types of therapeutic activities are suggested as a fit for this award?
The opportunity description suggests projects that generate evidence needed for the next development step, such as refining a candidate intervention, demonstrating proof-of-concept in appropriate models, characterizing activity and feasibility, and producing data that de-risks later-stage development.
11) Is this opportunity intended to support late-stage clinical trials?
No. The description emphasizes early and preclinical development for therapeutics and does not describe support for late-stage clinical trials.
12) What is the focus of diagnostic projects under this award?
Diagnostic projects are expected to focus on approaches that can be readily integrated into clinical settings. Proposals should aim toward tests or diagnostic workflows that can realistically fit into healthcare practice and have a clear pathway toward adoption in patient care.
13) What does "readily integrated into clinical settings" imply for diagnostics?
It implies attention to practical implementation considerations such as clinical usability, feasibility in typical laboratory or point-of-care environments, and a design approach that supports eventual routine clinical use (not just technical novelty).
14) How does the program define success or impact?
The central focus is on reducing disease burden while improving patient care and quality of life. Proposals are expected to contribute to that goal through tangible deliverables that move therapies or diagnostics toward real-world use.
15) Who is eligible to apply?
Eligible applicants are listed as unrestricted, meaning the program is open to a broad range of applicant organizations rather than being limited to a narrow class.
16) What is the CFDA number and activity category associated with this opportunity?
The opportunity is under the Science and Technology and other Research and Development activity category with CFDA 12.420.
17) How many awards are anticipated?
The posting indicates an anticipated total of two awards.
18) What is the application deadline?
The original closing date listed is October 22, 2026.
19) When was this opportunity created/posted?
The opportunity was created on May 5, 2026.
20) Where can applicants find additional details or related context?
Additional details and any pre-announcement context are referenced via the CDMRP page: https://cdmrp.health.mil/pubs/press/2026/tbdrppreann.
21) What is the main difference in emphasis between the therapeutic and diagnostic tracks?
Therapeutics are framed around early/preclinical development and evaluation work that supports advancing a candidate intervention and de-risking later development. Diagnostics are framed around clinical integration, usability, feasibility in real clinical environments, and a clear pathway to adoption in patient care.
22) Does the opportunity prioritize exploratory or basic research?
No. The description indicates proposals should be oriented toward tangible deliverables and practical products rather than purely exploratory or basic research.
23) What does "moving closer to real-world use" mean in this context?
In the context provided, it means generating development-oriented outcomes that help position a therapy or diagnostic for practical implementation, including evidence and deliverables that support the next step toward use in patient care.
24) What should an applicant keep front-and-center when designing a project for this award?
Applicants should keep the program's stated intent in focus: product-driven, tangible deliverables that reduce disease burden and improve patient care and quality of life, with therapeutics positioned for early/preclinical development progress and diagnostics designed for realistic clinical integration.
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