Opportunity Information: Apply for PAR 27 082
The NIAID Investigator-Initiated Program Project Applications opportunity (PAR-27-082) is a National Institutes of Health discretionary grant program that supports large, integrated research efforts through the P01 mechanism. It is designed for teams of investigators who want to pursue a coordinated set of scientifically linked projects under a single overarching program, rather than a collection of independent studies. A key point in the title and requirements is that this is a "Clinical Trial Not Allowed" funding opportunity, meaning applicants must propose research that does not meet the NIH definition of a clinical trial; studies involving human participants may still be possible in some cases, but the application cannot include an intervention study intended to evaluate effects on health-related outcomes.
Scientifically, the NOFO is broad but firmly centered on the NIAID mission, emphasizing infectious diseases and immunology. Competitive programs may address the biology and pathogenesis of infectious microbes, including HIV, and the ways hosts and microbes interact during infection. It also encourages work on immune system development and function across the lifespan, as well as immune responses to infectious pathogens. Another major theme is immune dysfunction, including conditions such as allergy, asthma, autoimmunity, immunodeficiency, and transplant rejection, particularly where those conditions relate to immune mechanisms and responses to pathogens. In addition to foundational mechanistic work, the NOFO explicitly welcomes translational research aimed at advancing vaccines, therapeutics, and diagnostics intended to prevent, detect, or treat infectious and immune-mediated diseases, as long as the proposed activities remain outside the clinical trial space.
Structurally, applications must be true program projects with synergy built in. Each submission is required to include at least two related and collaborative Research Projects that are connected by a shared central theme, focus, and/or overall objective. The expectation is that these projects reinforce one another in a way that produces added scientific value compared with funding the projects separately. Every application must also include an Administrative Core, which typically covers overall leadership, governance, communication, coordination, progress tracking, and program management across the component projects. In addition, applicants may propose one or more Scientific Cores if they are justified by the research plan. These cores generally provide shared resources, specialized services, technologies, data coordination, or other enabling infrastructure that multiple projects rely on, helping create efficiency and consistency across the program.
Eligibility is broad for U.S.-based organizations across many sectors, including public and private institutions of higher education, state and local governments, tribal governments and tribal organizations, independent school districts, special district governments, public housing authorities/Indian housing authorities, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits that are not small businesses), and other eligible entities as permitted by NIH policy. However, the NOFO is clear about international restrictions: non-U.S. entities (foreign organizations) cannot apply, and non-U.S. components of U.S. organizations are also not eligible to apply as components. At the same time, "foreign components" as defined by the NIH Grants Policy Statement are allowed, meaning a U.S. applicant may include certain types of foreign involvement under NIH rules, but the applicant organization itself must be domestic and the arrangement must meet NIH requirements for foreign components.
From an administrative standpoint, the sponsoring agency is NIH (specifically NIAID), the activity category is Health, and the CFDA/Assistance Listing number is 93.855. The opportunity was created on 2026-05-07, and the listed original closing date runs through 2029-05-25, indicating a multi-year availability window with standard NIH submission cycles during that period. The listing does not specify an award ceiling or expected number of awards in the provided fields, so applicants would typically look to the full NOFO and NIAID guidance for budget expectations, program scope norms, and any institute-specific funding considerations.
Overall, this opportunity is aimed at well-integrated, multi-project research programs that can demonstrate a unifying theme, clear scientific interdependence among projects, strong leadership and coordination through an Administrative Core, and (when needed) shared infrastructure through Scientific Cores, all aligned with NIAID priorities in infectious diseases, immunology, immune dysregulation, and translational development of countermeasures, while staying within the "no clinical trials" boundary.Apply for PAR 27 082
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on 2026-05-07.
- Applicants must submit their applications by 2029-05-25.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIAID Investigator-Initiated Program Project Applications (PAR-27-082)
What is PAR-27-082?
PAR-27-082 is an NIH (NIAID) discretionary funding opportunity that supports large, integrated research efforts through the P01 (Program Project) grant mechanism. It is intended for coordinated teams pursuing a set of scientifically linked projects organized around a single overarching program, rather than unrelated or independent studies packaged together.
What does the P01 mechanism support in practical terms?
The P01 mechanism supports a multi-project program where multiple research projects are intentionally designed to reinforce each other. The program is expected to generate added scientific value through integration and collaboration, beyond what would be achieved if each project were funded separately.
Is this opportunity limited to clinical research?
No. The funding opportunity is broad, but it is explicitly labeled "Clinical Trial Not Allowed." This means the proposed work must not meet the NIH definition of a clinical trial. Some studies involving human participants may still be possible, but the application cannot include an intervention study intended to evaluate effects on health-related outcomes.
What does "Clinical Trial Not Allowed" mean for applicants?
"Clinical Trial Not Allowed" means you cannot propose research that meets the NIH definition of a clinical trial. In general terms (based on the opportunity description), you may be able to include certain human-participant research, but you cannot include an intervention study designed to evaluate the effects of that intervention on health-related outcomes.
What scientific areas are a good fit for this NIAID program?
The opportunity is centered on the NIAID mission, with emphasis on infectious diseases and immunology. Competitive programs may include work on infectious microbes (including HIV), mechanisms of pathogenesis, and host-microbe interactions during infection.
Does the opportunity include immunology beyond infectious disease?
Yes. It encourages research on immune system development and function across the lifespan and immune responses to infectious pathogens. It also includes immune dysfunction areas such as allergy, asthma, autoimmunity, immunodeficiency, and transplant rejection, especially where these relate to immune mechanisms and responses to pathogens.
Is translational research allowed under this NOFO?
Yes. The description explicitly welcomes translational research aimed at advancing vaccines, therapeutics, and diagnostics to prevent, detect, or treat infectious and immune-mediated diseases, as long as the proposed activities remain outside the clinical trial space.
How many research projects are required in a P01 application under this opportunity?
Applications must include at least two related and collaborative Research Projects that share a central theme, focus, and/or overall objective. The projects should be scientifically linked and designed to work together.
What does NIH/NIAID mean by "synergy" in a program project?
Synergy means the projects are interdependent and reinforce one another, producing added scientific value compared to funding the projects separately. The application should demonstrate real integration rather than a loose collection of projects.
Is an Administrative Core required?
Yes. Every application must include an Administrative Core. The Administrative Core typically covers overall leadership and governance, communication and coordination among projects, progress tracking, and program management across the full set of components.
Are Scientific Cores required?
No. Scientific Cores are optional. Applicants may propose one or more Scientific Cores if they are justified by the research plan.
What do Scientific Cores typically do in a P01?
Scientific Cores generally provide shared resources, specialized services, technologies, data coordination, or other enabling infrastructure used by multiple projects. Their purpose is to create efficiency, consistency, and capabilities that support the integrated program.
Who is eligible to apply?
Eligibility is broad for U.S.-based organizations and includes many sectors such as public and private institutions of higher education; state and local governments; tribal governments and tribal organizations; independent school districts; special district governments; public housing authorities/Indian housing authorities; nonprofits (with or without 501(c)(3) status); and for-profit organizations (including small businesses and other for-profits that are not small businesses), as permitted by NIH policy.
Can a non-U.S. (foreign) organization apply as the applicant?
No. The NOFO states that non-U.S. entities (foreign organizations) cannot apply.
Can a non-U.S. component of a U.S. organization apply as a component?
No. The NOFO indicates that non-U.S. components of U.S. organizations are not eligible to apply as components.
Are any kinds of international involvement allowed at all?
Yes. "Foreign components" (as defined by the NIH Grants Policy Statement) are allowed. This means a U.S. applicant organization may include certain types of foreign involvement under NIH rules, but the applicant organization must be domestic and the arrangement must meet NIH requirements for foreign components.
Which NIH institute is sponsoring this opportunity?
The sponsoring agency is NIH, specifically the National Institute of Allergy and Infectious Diseases (NIAID).
What is the Assistance Listing (CFDA) number for this opportunity?
The CFDA/Assistance Listing number provided is 93.855.
What is the activity category?
The activity category listed is Health.
When was this opportunity created, and how long is it available?
The opportunity was created on 2026-05-07. The listed original closing date runs through 2029-05-25, indicating a multi-year availability window with standard NIH submission cycles during that period.
Does the listing provide an award ceiling or the expected number of awards?
No. The provided listing fields do not specify an award ceiling or an expected number of awards. Applicants would typically consult the full NOFO and NIAID guidance for budget expectations, typical program scope, and any institute-specific funding considerations.
What makes an application a strong fit based on the description provided?
Based on the description, strong applications are well-integrated, multi-project programs that (1) show a unifying theme aligned with NIAID priorities in infectious diseases, immunology, immune dysregulation, and/or translational countermeasure development; (2) demonstrate clear scientific interdependence and synergy among at least two collaborative research projects; (3) provide strong leadership and coordination through an Administrative Core; (4) include Scientific Cores when shared infrastructure is justified; and (5) stay within the "Clinical Trial Not Allowed" boundary.
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