Opportunity Information: Apply for PAR 17 245
Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01) is a National Institutes of Health (NIH) discretionary grant funding opportunity (Funding Opportunity Number PAR-17-245) focused on strengthening mammalian cancer and tumor models so they are more useful for translational research. In practical terms, the program supports research projects that expand, improve, or meaningfully transform existing mammalian model systems used to study cancer, with an emphasis on making those models better suited to bridge the gap between basic discovery and clinical application. The central goal is to generate models that more accurately reflect human disease biology and therefore can produce findings that are more predictive of what will happen in patients, such as treatment response, resistance mechanisms, tumor evolution, or microenvironment effects.
The award mechanism is the NIH R01, which is typically used for hypothesis-driven, investigator-initiated research projects with clearly defined aims and a substantial body of work. The opportunity is categorized under Education and Health and is associated with multiple CFDA numbers (93.393, 93.394, 93.395, 93.396), reflecting its placement within NIH cancer-related research programs. The FOA was created on 2017-04-03 and listed an original closing date of 2020-03-12. The posted award ceiling is $450,000 (as provided in the source information), which indicates the maximum funding level described in the opportunity details, though actual budgets and allowable costs are governed by NIH grants policy and the specific terms of the announcement.
A notable feature of this FOA is the breadth of organizations that may apply. Eligibility includes a wide range of government entities (state, county, city or township governments, and special district governments), as well as independent school districts and public housing authorities/Indian housing authorities. Higher education institutions are broadly eligible, including public and state-controlled institutions of higher education and private institutions of higher education. Tribal eligibility includes federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized governments. The FOA also welcomes nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories), as well as for-profit organizations other than small businesses and small businesses. Beyond those standard categories, the announcement explicitly highlights additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). This wide eligibility scope is consistent with NIH’s interest in drawing expertise from many sectors to improve translational model systems.
Overall, this funding opportunity is designed for teams developing or refining mammalian cancer and tumor models in ways that materially increase their translational value. Competitive projects under an FOA like this typically make a clear case for why current models fall short for a defined translational need and propose a rigorous plan to overcome those limitations, resulting in model systems that can better support therapy development, biomarker work, or mechanistic studies that are more likely to translate into clinical benefit.Apply for PAR 17 245
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396.
- This funding opportunity was created on 2017-04-03.
- Applicants must submit their applications by 2020-03-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $450,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Extracellular Vesicles and Substance Use Disorders (R01) Apply for PAR 17 250 Funding Number: PAR 17 250 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Expanding Medication Assisted Treatment for Opioid Use Disorders in the Context of the SAMHSA Opioid STR Grants (R21/R33) Apply for RFA DA 18 005 Funding Number: RFA DA 18 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Nasal Delivery of CNS Therapeutics (R43/R44) Apply for RFA DA 18 006 Funding Number: RFA DA 18 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Nasal Delivery of CNS Therapeutics (R41/R42) Apply for RFA DA 18 007 Funding Number: RFA DA 18 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Role of Myeloid Cells in Persistence and Eradication of HIV-1 Reservoirs from the Brain (R01) Apply for RFA MH 18 300 Funding Number: RFA MH 18 300 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Role of Myeloid Cells in Persistence and Eradication of HIV-1 Reservoirs from the Brain (R21) Apply for RFA MH 18 301 Funding Number: RFA MH 18 301 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Genomic Community Resources (U24) Apply for PAR 17 273 Funding Number: PAR 17 273 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| In Vitro and Animal Model Studies on HBV/HIV Co-Infection (R01) Apply for PA 17 280 Funding Number: PA 17 280 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HIV and Hepatitis B Co-Infection: Advancing HBV Functional Cure through Clinical Research (R01) Apply for PA 17 279 Funding Number: PA 17 279 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Wearable to Track Recovery and Relapse Factors for People w/ Addiction(R43/R44) Apply for RFA DA 18 010 Funding Number: RFA DA 18 010 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploring Novel RNA Modifications in HIV/AIDS and Substance Use Disorders (R01) Apply for RFA DA 18 008 Funding Number: RFA DA 18 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploring Novel RNA Modifications in HIV/AIDS and Substance Use Disorders (R21) Apply for RFA DA 18 009 Funding Number: RFA DA 18 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| In Vitro and Animal Model Studies on HBV/HIV Co-Infection (R21) Apply for PA 17 281 Funding Number: PA 17 281 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| HIV and Hepatitis B Co-Infection: Advancing HBV Functional Cure through Clinical Research (R21) Apply for PA 17 278 Funding Number: PA 17 278 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Leveraging Population-based Cancer Registry Data to Study Health Disparities (R01) Apply for PA 17 289 Funding Number: PA 17 289 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Leveraging Population-based Cancer Registry Data to Study Health Disparities (R21) Apply for PA 17 288 Funding Number: PA 17 288 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Addressing Suicide Research Gaps: Aggregating and Mining Existing Data Sets for Secondary Analyses (R01) Apply for RFA MH 18 400 Funding Number: RFA MH 18 400 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Silencing of HIV-1 Proviruses (R61/R33) Apply for RFA AI 17 013 Funding Number: RFA AI 17 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| U.S. Tobacco Control Policies to Reduce Health Disparities (R01) Apply for PAR 17 217 Funding Number: PAR 17 217 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| U.S. Tobacco Control Policies to Reduce Health Disparities (R21) Apply for PAR 17 218 Funding Number: PAR 17 218 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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