Opportunity Information: Apply for PAR 17 245
Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01) is a National Institutes of Health (NIH) discretionary grant funding opportunity (Funding Opportunity Number PAR-17-245) focused on strengthening mammalian cancer and tumor models so they are more useful for translational research. In practical terms, the program supports research projects that expand, improve, or meaningfully transform existing mammalian model systems used to study cancer, with an emphasis on making those models better suited to bridge the gap between basic discovery and clinical application. The central goal is to generate models that more accurately reflect human disease biology and therefore can produce findings that are more predictive of what will happen in patients, such as treatment response, resistance mechanisms, tumor evolution, or microenvironment effects.
The award mechanism is the NIH R01, which is typically used for hypothesis-driven, investigator-initiated research projects with clearly defined aims and a substantial body of work. The opportunity is categorized under Education and Health and is associated with multiple CFDA numbers (93.393, 93.394, 93.395, 93.396), reflecting its placement within NIH cancer-related research programs. The FOA was created on 2017-04-03 and listed an original closing date of 2020-03-12. The posted award ceiling is $450,000 (as provided in the source information), which indicates the maximum funding level described in the opportunity details, though actual budgets and allowable costs are governed by NIH grants policy and the specific terms of the announcement.
A notable feature of this FOA is the breadth of organizations that may apply. Eligibility includes a wide range of government entities (state, county, city or township governments, and special district governments), as well as independent school districts and public housing authorities/Indian housing authorities. Higher education institutions are broadly eligible, including public and state-controlled institutions of higher education and private institutions of higher education. Tribal eligibility includes federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized governments. The FOA also welcomes nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories), as well as for-profit organizations other than small businesses and small businesses. Beyond those standard categories, the announcement explicitly highlights additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). This wide eligibility scope is consistent with NIH’s interest in drawing expertise from many sectors to improve translational model systems.
Overall, this funding opportunity is designed for teams developing or refining mammalian cancer and tumor models in ways that materially increase their translational value. Competitive projects under an FOA like this typically make a clear case for why current models fall short for a defined translational need and propose a rigorous plan to overcome those limitations, resulting in model systems that can better support therapy development, biomarker work, or mechanistic studies that are more likely to translate into clinical benefit.Apply for PAR 17 245
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396.
- This funding opportunity was created on 2017-04-03.
- Applicants must submit their applications by 2020-03-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $450,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-17-245.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary grant funding opportunity.
What is the overall purpose of this FOA?
The purpose is to support research that expands, improves, or meaningfully transforms existing mammalian cancer and tumor model systems so they are more useful for translational research.
What does "enhancing applicability of mammalian models" mean in practical terms?
It means developing or refining mammalian model systems used to study cancer in ways that make them better suited to bridge basic discovery and clinical application, including making models more reflective of human disease biology.
What kinds of scientific outcomes is the program aiming for?
The central goal is to generate models that more accurately reflect human disease biology and can produce findings that are more predictive of what will happen in patients, such as:
- treatment response
- resistance mechanisms
- tumor evolution
- microenvironment effects
What grant mechanism is used for this opportunity?
The award mechanism is the NIH R01.
What type of projects are typically associated with an NIH R01?
An NIH R01 is typically used for hypothesis-driven, investigator-initiated research projects with clearly defined aims and a substantial body of work.
What research area or topic does this opportunity focus on?
It focuses on cancer and tumor models in mammalian systems, with an emphasis on improving their translational usefulness.
How is this opportunity categorized?
The opportunity is categorized under Education and Health.
Which CFDA numbers are associated with this FOA?
This opportunity is associated with multiple CFDA numbers: 93.393, 93.394, 93.395, and 93.396.
When was this FOA created?
The FOA was created on 2017-04-03.
What was the original closing date listed for this FOA?
The original closing date listed is 2020-03-12.
What is the posted award ceiling?
The posted award ceiling is $450,000 (as provided in the source information).
Does the award ceiling guarantee that applicants can request or receive $450,000?
The $450,000 figure is described as the maximum funding level in the opportunity details. Actual budgets and allowable costs are governed by NIH grants policy and the specific terms of the announcement.
Who is eligible to apply?
Eligibility is broad and includes government entities, education institutions, tribal organizations, nonprofits, and for-profit organizations, among others, as described in the announcement.
What types of government entities are eligible?
Eligible government applicants include:
- state governments
- county governments
- city or township governments
- special district governments
Are school districts and housing authorities eligible?
Yes. Eligibility includes independent school districts and public housing authorities/Indian housing authorities.
Are colleges and universities eligible?
Yes. Eligible higher education institutions include:
- public and state-controlled institutions of higher education
- private institutions of higher education
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes:
- federally recognized Native American tribal governments
- Native American tribal organizations that are not federally recognized governments
Are nonprofit organizations eligible?
Yes. The FOA welcomes nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories, as stated in the announcement).
Are for-profit organizations eligible?
Yes. Eligibility includes for-profit organizations other than small businesses and also includes small businesses.
Are Minority Serving Institutions (MSIs) explicitly included as eligible applicants?
Yes. The announcement explicitly highlights eligible applicant types including:
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
Are faith-based or community-based organizations eligible to apply?
Yes. The FOA explicitly includes faith-based or community-based organizations as eligible applicant types.
Are federal agencies eligible to apply?
Yes. The announcement includes eligible federal agencies.
Are U.S. territories or possessions eligible?
Yes. The FOA includes U.S. territories or possessions among eligible applicant types.
Are non-U.S. (foreign) organizations eligible?
Yes. The opportunity includes non-domestic (non-U.S.) entities (foreign organizations) as eligible applicant types.
What types of projects are likely to be competitive under this FOA?
Competitive projects typically (as described in the provided information) make a clear case for:
- why current mammalian cancer/tumor models fall short for a defined translational need
- a rigorous plan to overcome those limitations
- how the resulting model system will materially increase translational value (for example, better supporting therapy development, biomarker work, or mechanistic studies that are more likely to translate into clinical benefit)
What is the intended impact of improving these mammalian models?
The intended impact is to produce models that are more predictive of patient outcomes and therefore can better support translation from basic research into clinically relevant insights, including understanding treatment response and resistance, tumor evolution, and the tumor microenvironment.
Browse more opportunities from the same category: Education, Health
Next opportunity: Agriculture and Food Research Initiative - Sustainable Bioenergy and Bioproducts Challenge Area
Previous opportunity: Research Answers to NCI's Provocative Questions (R21)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 17 245
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 17 245) also looked into and applied for these:
| Funding Opportunity |
|---|
| Extracellular Vesicles and Substance Use Disorders (R01) Apply for PAR 17 250 Funding Number: PAR 17 250 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Expanding Medication Assisted Treatment for Opioid Use Disorders in the Context of the SAMHSA Opioid STR Grants (R21/R33) Apply for RFA DA 18 005 Funding Number: RFA DA 18 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Nasal Delivery of CNS Therapeutics (R43/R44) Apply for RFA DA 18 006 Funding Number: RFA DA 18 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Nasal Delivery of CNS Therapeutics (R41/R42) Apply for RFA DA 18 007 Funding Number: RFA DA 18 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Role of Myeloid Cells in Persistence and Eradication of HIV-1 Reservoirs from the Brain (R01) Apply for RFA MH 18 300 Funding Number: RFA MH 18 300 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Role of Myeloid Cells in Persistence and Eradication of HIV-1 Reservoirs from the Brain (R21) Apply for RFA MH 18 301 Funding Number: RFA MH 18 301 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Genomic Community Resources (U24) Apply for PAR 17 273 Funding Number: PAR 17 273 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| In Vitro and Animal Model Studies on HBV/HIV Co-Infection (R01) Apply for PA 17 280 Funding Number: PA 17 280 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HIV and Hepatitis B Co-Infection: Advancing HBV Functional Cure through Clinical Research (R01) Apply for PA 17 279 Funding Number: PA 17 279 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Wearable to Track Recovery and Relapse Factors for People w/ Addiction(R43/R44) Apply for RFA DA 18 010 Funding Number: RFA DA 18 010 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploring Novel RNA Modifications in HIV/AIDS and Substance Use Disorders (R01) Apply for RFA DA 18 008 Funding Number: RFA DA 18 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploring Novel RNA Modifications in HIV/AIDS and Substance Use Disorders (R21) Apply for RFA DA 18 009 Funding Number: RFA DA 18 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| In Vitro and Animal Model Studies on HBV/HIV Co-Infection (R21) Apply for PA 17 281 Funding Number: PA 17 281 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| HIV and Hepatitis B Co-Infection: Advancing HBV Functional Cure through Clinical Research (R21) Apply for PA 17 278 Funding Number: PA 17 278 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Leveraging Population-based Cancer Registry Data to Study Health Disparities (R01) Apply for PA 17 289 Funding Number: PA 17 289 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Leveraging Population-based Cancer Registry Data to Study Health Disparities (R21) Apply for PA 17 288 Funding Number: PA 17 288 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Addressing Suicide Research Gaps: Aggregating and Mining Existing Data Sets for Secondary Analyses (R01) Apply for RFA MH 18 400 Funding Number: RFA MH 18 400 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Silencing of HIV-1 Proviruses (R61/R33) Apply for RFA AI 17 013 Funding Number: RFA AI 17 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| U.S. Tobacco Control Policies to Reduce Health Disparities (R01) Apply for PAR 17 217 Funding Number: PAR 17 217 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| U.S. Tobacco Control Policies to Reduce Health Disparities (R21) Apply for PAR 17 218 Funding Number: PAR 17 218 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 17 245", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.