Chronic Kidney Disease in Children Central Biochemistry Laboratory (U24 Clinical Trial Not Allowed) | RFA DK 23 002

Opportunity Information: Apply for RFA DK 23 002

The Chronic Kidney Disease in Children Central Biochemistry Laboratory (U24 Clinical Trial Not Allowed) funding opportunity (RFA-DK-23-002) is a National Institutes of Health (NIH) cooperative agreement intended to support a centralized laboratory that provides biochemistry testing and related services for the Chronic Kidney Disease in Children (CKiD) Consortium. The lead institute is the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), working in collaboration with the National Heart, Lung and Blood Institute (NHLBI) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The core purpose is to establish or maintain a Central Biochemistry Laboratory (CBL) that can operate as a shared resource for the consortium, producing consistent, high-quality laboratory data that can be integrated across participating clinical sites and over time.

This award uses the U24 mechanism, which is a cooperative agreement. That matters because it signals an active, ongoing partnership between the NIH and the awardee rather than a hands-off grant. The CBL is expected to work cooperatively as part of a broader consortium structure that already includes Clinical Coordinating Centers (CCCs) and a Data Coordinating Center (DCC). In practical terms, the funded laboratory would be expected to coordinate closely with these existing centers around specimen handling workflows, assay selection and performance, quality assurance and quality control practices, reporting formats, timelines, and data transfer procedures so that laboratory results are comparable, reliable, and ready for centralized analysis. The notice also specifies "Clinical Trial Not Allowed," meaning the funded activities should not include conducting an NIH-defined clinical trial; the laboratory role is focused on testing and support functions for the ongoing research infrastructure rather than initiating or running interventional clinical studies.

The opportunity is categorized under discretionary funding and falls within health-related activity areas, with associated CFDA numbers 93.837, 93.847, and 93.865. While the listing does not provide an award ceiling, expected number of awards, or other budget specifics in the provided text, it clearly frames the award as supporting a consortium-wide core laboratory function rather than a single-investigator research project. The original application closing date listed is January 12, 2023, and the opportunity was created on November 18, 2022.

Eligibility is broad and includes many U.S.-based governmental, academic, nonprofit, and commercial organizations. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible agencies of the federal government, Indian/Native American tribal governments other than federally recognized entities, and U.S. territories or possessions.

At the same time, the opportunity draws a firm line on foreign eligibility. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, it allows "foreign components" as defined in the NIH Grants Policy Statement, which typically means that while the applicant organization must be domestic and the main work cannot be based in a non-U.S. component of a U.S. organization, certain well-justified elements of the work may be carried out internationally under NIH rules when appropriate and properly documented.

Overall, the opportunity is best understood as an infrastructure and operations award to run the centralized biochemistry lab function for a major pediatric chronic kidney disease research consortium. The funded CBL is expected to be an integrated partner with the consortiums coordinating and data centers, delivering standardized lab measurements and supporting the flow of high-integrity biospecimen-derived data into the CKiD research enterprise, without undertaking clinical trial activities under this award.

• The National Institutes of Health in the food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Chronic Kidney Disease in Children Central Biochemistry Laboratory (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837, 93.847, 93.865.
• This funding opportunity was created on 2022-11-18.
• Applicants must submit their applications by 2023-01-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA DK 23 002

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